The neuroprotective effect of treatment with curcumin in acute spinal cord injury: laboratory investigation.
RatSpinal cord injuryCompressionSprague-DawleyMalen = 36 rats, 12 per group across sham, curcumin and vehicle gro…Intraperitoneal injection200 mg/kg per day dissolved in 1.0 mL dimethyl sulfoxideStarted on the day of injury
Model: Clip compression spinal cord injury: laminectomy at T9 and application of a modified aneurysm clip with 30 g closing force vertically onto the exposed cord for 2 minutes, under intraperitoneal xylazine 10 mg/kg and ketamine 60 mg/kg anaesthesia
Curcumin improved every endpoint: BBB scores were higher than vehicle from day 7 (P<0.05), cavitation volume fell from 2.21 (SD 0.31) to 1.18 (SD 0.20) mm3 (P=0.039) with more spared tissue at the epicentre (P=0.006), ED-1 macrophage activity was 27.1% lower at 2 weeks (P=0.001), plasma superoxide…
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