Inhibition of gene expression of carnitine palmitoyltransferase I and heart fatty acid binding protein in cyclophosphamide and ifosfamide-induced acute cardiotoxic rat models.
RatChemical/toxinWistar albinoMalen = Six treatment groups; number of animals per group not statedIntraperitoneal injection200 mg/kg per dayGiven for 5 days before and 5 days after a single cyclophosphamide dose, or for…
Model: Acute cardiotoxicity induced by a single intraperitoneal dose of cyclophosphamide 200 mg/kg or by ifosfamide 50 mg/kg per day intraperitoneally for 5 days
Cyclophosphamide and ifosfamide reduced cardiac heart fatty acid binding protein and carnitine palmitoyltransferase I expression and raised lactate dehydrogenase, creatine kinase MB and malonyl-CoA with histopathological lesions; carnitine supplementation reversed all biochemical, histopathological…
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