Effect of mixed transplantation of autologous and allogeneic microskin grafts on wound healing in a rat model of acute skin defect.
RatWoundSprague-Dawley recipients; Wistar allogeneic donorsFemale recipients; male donorsn = Experiment A: 40 female Sprague-Dawley rats (4 groups of 10…Topical transplantation onto the excised wound bed under liquid paraffin gauzeArea expansion ratios: autologous 10:1 with allogeneic 10:1…Immediately, at the time of wound creation
Model: Full-thickness 4.0 cm x 6.0 cm dorsal skin defect with panniculus carnosus left intact
Mixed grafting substantially improved the wound healing rate compared with autologous microskin alone. Autologous 10:1 combined with allogeneic 10:1 gave the highest healing rate and the highest ectopic epidermal integrin beta1 expression. Wound contraction rates differed little between groups.
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