THERAPY DOSSIER · th-9c65ce79f3a7

Mixed autologous and allogeneic microskin grafts (particles under 1 mm, from 0.3 mm partial-thickness grafts)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24465646 ↗2014Reported benefit

Effect of mixed transplantation of autologous and allogeneic microskin grafts on wound healing in a rat model of acute skin defect.

RatWoundSprague-Dawley recipients; Wistar allogeneic donorsFemale recipients; male donorsn = Experiment A: 40 female Sprague-Dawley rats (4 groups of 10…Topical transplantation onto the excised wound bed under liquid paraffin gauzeArea expansion ratios: autologous 10:1 with allogeneic 10:1…Immediately, at the time of wound creation

Model: Full-thickness 4.0 cm x 6.0 cm dorsal skin defect with panniculus carnosus left intact

Mixed grafting substantially improved the wound healing rate compared with autologous microskin alone. Autologous 10:1 combined with allogeneic 10:1 gave the highest healing rate and the highest ectopic epidermal integrin beta1 expression. Wound contraction rates differed little between groups.

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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