Estrogen-provided cardiac protection following burn trauma is mediated through a reduction in mitochondria-derived DAMPs.
RatBurnScaldSprague-DawleyMaleSubcutaneous injection0.5 mg/kg15 minutes after burn
Model: Third degree scald burn covering 40% of total body surface area
Post-burn 17-beta-estradiol reduced mitochondrial oxidative damage and release of mitochondrial danger associated molecular patterns, lowered myocardial apoptosis and inflammatory signalling, reduced troponin I and improved cardiac morphology and contractility 24 hours after burn
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