Locally mediated analgesic effect of bradykinin type 2 receptor antagonist HOE 140 during acute inflammatory pain in rats.
RatWoundSprague-DawleyMaleDirect intrawound (local) administration by sterile micropipette; contralateral paw administration used as a control for systemic action1, 3 or 10 micrograms in 10 microlitres of physiological sa…Into the open wound immediately after incision, 30 seconds before wound closure
Model: Surgical incision involving skin, fascia and muscle (postincisional inflammatory pain model, used as a proxy for burn pain)
HOE 140 at 1, 3 and 10 micrograms significantly relieved mechanical allodynia and guarding compared with vehicle. The effect was locally mediated, and wound healing was normal.
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