Effects of hyperbaric oxygen on MMP-2 and MMP-9 expression and spinal cord edema after spinal cord injury.
RatSpinal cord injuryUnspecifiedSprague-Dawleyn = 96 rats in 4 groups, each subdivided into 4 time-point subg…Hyperbaric chamberAfter acute spinal cord injury
Model: Acute spinal cord injury
Hyperbaric oxygen significantly lowered MMP-2 at 72 h and MMP-9 at 48 h, 72 h and 5 days after injury, and reduced spinal cord oedema. MMP-2 and MMP-9 levels correlated positively with spinal cord water content.
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