Neuroprotective effects of GDNF-expressing human amniotic fluid cells.
MouseTBIUnspecifiedC57BL/6FemaleImplantation into the lesion cavity on a polyglycolic acid scaffoldAcutely after injury
Model: Surgically induced brain injury creating a lesion cavity in the motor cortex
AF-GDNF cells survived longer than control cells and continued to secrete GDNF after implantation, and activated MAPK/ERK signalling in host peri-lesion cells. Beam walking showed only promising trends over the 7 day window, with no demonstrated significant behavioural improvement.
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