THERAPY DOSSIER · th-8fd4c549129a

Human amniotic fluid single cell clones engineered to secrete glial cell derived neurotrophic factor (AF-GDNF), seeded on polyglycolic acid scaffolds

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06285643 ↗PHASE2recruiting

Intraputaminal AAV2-GDNF in moderate stage Parkinson's disease

Parkinson Disease

Enrolment: 127 · Results not recorded

NCT05306457 ↗PHASE1active not recruiting

CNS10-NPC-GDNF: human neural progenitor cells secreting GDNF delivered to motor cortex in ALS

Amyotrophic Lateral Sclerosis

Enrolment: 16 · Results not recorded

NCT01621581 ↗PHASE1completed

CED of AAV2-GDNF in advanced Parkinson's disease

Parkinson's Disease

Enrolment: 25 · Results not recorded

NCT04680065 ↗PHASE1active not recruiting

AAV2-GDNF gene transfer in multiple system atrophy

Multiple System Atrophy

Enrolment: 9 · Results not recorded

NCT00115427 ↗PHASE1completed

Liatermin (r-metHuGDNF) bilateral intraputaminal infusion in idiopathic Parkinson's disease

Idiopathic Parkinson's Disease

Enrolment not recorded · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24415130 ↗2014Mixed findings

Neuroprotective effects of GDNF-expressing human amniotic fluid cells.

MouseTBIUnspecifiedC57BL/6FemaleImplantation into the lesion cavity on a polyglycolic acid scaffoldAcutely after injury

Model: Surgically induced brain injury creating a lesion cavity in the motor cortex

AF-GDNF cells survived longer than control cells and continued to secrete GDNF after implantation, and activated MAPK/ERK signalling in host peri-lesion cells. Beam walking showed only promising trends over the 7 day window, with no demonstrated significant behavioural improvement.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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