Inhibition of NADPH oxidase prevents acute lung injury in obese rats following severe trauma.
RatFractureUnspecifiedZucker (lean and obese)MaleAfter trauma
Model: Severe hindlimb trauma by muscle injury, fibula fracture and bone component injection to both hindlimbs, causing acute lung injury
Obese rats showed greater increases in lung capillary filtration coefficient, neutrophil accumulation, NOX and myeloperoxidase activity and plasma IL-6 after trauma than lean rats. Apocynin reduced all of these measures and the wet to dry weight ratio in obese rats.
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