Hepatoprotective action of Echinophora platyloba DC leaves against acute toxicity of acetaminophen in rats.
RatChemical/toxinn = 48 rats in 6 groupsOral gavage200, 500 and 1,000 mg/kg body weight; silymarin positive co…Pre-treatment, on days 1 and 2 before the acetaminophen challenge on day 2
Model: Acetaminophen-induced acute hepatotoxicity (400 mg/kg by gavage on day 2)
All extract doses significantly reduced elevated serum ALT, AST, ALP and malondialdehyde compared with the untreated injured group (P less than 0.05). The 1,000 mg/kg dose gave effects similar to the control and silymarin groups. Liver catalase activity, serum antioxidant capacity and histopatholog…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.