THERAPY DOSSIER · th-55e48b4f2c23

Echinophora platyloba DC leaf extract

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24409975 ↗2014Reported benefit

Hepatoprotective action of Echinophora platyloba DC leaves against acute toxicity of acetaminophen in rats.

RatChemical/toxinn = 48 rats in 6 groupsOral gavage200, 500 and 1,000 mg/kg body weight; silymarin positive co…Pre-treatment, on days 1 and 2 before the acetaminophen challenge on day 2

Model: Acetaminophen-induced acute hepatotoxicity (400 mg/kg by gavage on day 2)

All extract doses significantly reduced elevated serum ALT, AST, ALP and malondialdehyde compared with the untreated injured group (P less than 0.05). The 1,000 mg/kg dose gave effects similar to the control and silymarin groups. Liver catalase activity, serum antioxidant capacity and histopatholog…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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