Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice.
MouseEndotoxin/LPSWild-type C57BL/6J and adenosine receptor knockout mice on a C57BL/6 backgroundMalen = 15 mice per group for survival; 5 mice per group across 4 g…Intraperitoneal5 mg per 20 g body weightPre-treatment, 30 minutes before D-galactosamine/lipopolysaccharide challenge
Model: Acute liver failure induced by intraperitoneal D-galactosamine 500 mg/kg plus lipopolysaccharide (serotype O55:B5) 5 micrograms/kg
5'-AMP pre-treatment raised survival from 33.3% to 93.3% at 24 hours (log-rank P = 0.0007), lowered serum AST and ALT, reduced hepatocyte necrosis and inflammatory cell infiltration, and cut cytokine and chemokine production. Protection persisted in adenosine receptor knockout mice, showing recepto…
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