THERAPY DOSSIER · th-bb503d237539

Adenosine 5'-monophosphate (5'-AMP)

Drug · Unknown

Review required. This record is flagged as borderline.

Evidence & regulatory context

Mechanism: Unknown
Target: Not recorded
Injury models: Endotoxin/LPS
Reported indication: No current approval for the acute-injury (ischaemia) indication; ChEMBL flags the molecule withdrawn; historically compounded (adenosine phosphate), first_approval null
First approval: Not recorded
Development stage: Not approved for ischaemia; Phase 1 terminated; molecule flagged withdrawn
ChEMBL record: CHEMBL752 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: 5'-adenylic acid; A 5MP; A-5MP; Adenosine 5'-monophosphoric acid; Adenosine monophosphate (amp); Adenosine phosphate; Adenyl; Fosfato de adenosina; NSC-20264; Phosphate d'adenosine; Vitamin b8
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00179010 ↗PHASE1terminated

Use of AMP to Improve Tissue Delivery of Adenosine

Ischemia

Enrolment: 13 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24407238 ↗2014Reported benefit

Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice.

MouseEndotoxin/LPSWild-type C57BL/6J and adenosine receptor knockout mice on a C57BL/6 backgroundMalen = 15 mice per group for survival; 5 mice per group across 4 g…Intraperitoneal5 mg per 20 g body weightPre-treatment, 30 minutes before D-galactosamine/lipopolysaccharide challenge

Model: Acute liver failure induced by intraperitoneal D-galactosamine 500 mg/kg plus lipopolysaccharide (serotype O55:B5) 5 micrograms/kg

5'-AMP pre-treatment raised survival from 33.3% to 93.3% at 24 hours (log-rank P = 0.0007), lowered serum AST and ALT, reduced hepatocyte necrosis and inflammatory cell infiltration, and cut cytokine and chemokine production. Protection persisted in adenosine receptor knockout mice, showing recepto…

Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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