Successful improvement of blood pressure, cardiac output, and spinal cord blood flow after experimental spinal cord injury.
RatSpinal cord injuryCompressionFemalen = 37 rats across five groupsIntravenousInfused to maintain mean systemic arterial pressureInfusion started 15 minutes after injury
Model: 60 g clip compression injury at T1 for 1 minute in anaesthetised, ventilated rats
All four treatment infusions significantly improved the post-traumatic reduction in cardiac output, but only autologous whole blood and dextran reversed post-traumatic hypotension. Dextran raised central venous pressure and reduced haematocrit (both p less than 0.01). Whole blood improved spinal co…
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