THERAPY DOSSIER · th-37efb91e6c4d

Intravenous volume resuscitation with 5% albumin, autologous packed cells, low molecular weight dextran or autologous whole blood

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02654782 ↗PHASE2terminated

Lactated Ringer's Versus 5% Human Albumin in Cardiac Surgical Patients

Hemodynamic Stability

Enrolment: 10 · Results not recorded

NCT02767154 ↗PHASE2completed

Dextran-based Priming (PrimECC) vs Standard Crystalloid/Mannitol Priming in Adult Cardiac Surgery

Heart Disease

Enrolment: 84 · Results not recorded

NCT06835023 ↗NArecruiting

Fluid Resuscitation in Acute Pancreatitis: Dextran 40 and Ringer's Lactate vs Ringer's Lactate Alone

Acute Pancreatitis · Fluid Resuscitation

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 2439939 ↗1987Reported benefit

Successful improvement of blood pressure, cardiac output, and spinal cord blood flow after experimental spinal cord injury.

RatSpinal cord injuryCompressionFemalen = 37 rats across five groupsIntravenousInfused to maintain mean systemic arterial pressureInfusion started 15 minutes after injury

Model: 60 g clip compression injury at T1 for 1 minute in anaesthetised, ventilated rats

All four treatment infusions significantly improved the post-traumatic reduction in cardiac output, but only autologous whole blood and dextran reversed post-traumatic hypotension. Dextran raised central venous pressure and reduced haematocrit (both p less than 0.01). Whole blood improved spinal co…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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