Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds.
RatSpinal cord injuryHemisection / partialSprague-DawleyMaleIntrathecal deliveryApplied to acute lesions and separately to chronic lesions
Model: Dorsal funicular spinal cord lesion, treated in both the acute and the chronic phase
In acute lesions decorin reduced wound cavity area by 68 per cent, glia limitans accessoria encapsulation by 65 per cent, basal lamina thickness by 94 per cent and macrophage and microglial accumulation by 60 per cent, with smaller reductions in chronic lesions (cavity area 11 per cent, encapsulati…
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