Beneficial effects of Camellia Oil (Camellia oleifera Abel.) on ketoprofen-induced gastrointestinal mucosal damage through upregulation of HO-1 and VEGF.
RatChemical/toxinSprague-DawleyMale2 mL/kg/day in rats; 50 to 75 micrograms/mL in Int-407 cell…Pre-treatment, given prior to ketoprofen administration
Model: Ketoprofen 50 mg/kg/day induced acute gastric and intestinal mucosal ulceration
Camellia oil pre-treatment inhibited COX-2 expression, reduced interleukin-6 and nitric oxide production, reversed impairment of the antioxidant system and strongly reduced histologically confirmed gastrointestinal mucosal injury caused by ketoprofen.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.