Acellular spinal cord scaffold seeded with bone marrow stromal cells protects tissue and promotes functional recovery in spinal cord-injured rats.
RatSpinal cord injuryHemisection / partialSprague-DawleyMaleImplantation of the seeded scaffold into the injured spinal cord siteAt the time of injury surgery
Model: Acute hemisected spinal cord injury
Scaffolds seeded with bone marrow stromal cells produced significantly better locomotor recovery than scaffold alone or no treatment at 2 and 8 weeks (P<0.05), with surviving grafted cells differentiating into glial cells and reduced caspase-3 activation at 8 weeks (P<0.05).
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.