THERAPY DOSSIER · th-fce3e3c09142

Bone marrow stromal cells seeded on an acellular spinal cord scaffold

Biologic · Cell therapy + scaffold (bone marrow stromal cells on acellular spinal cord scaffold), preclinical; no matching trial identified

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Cell therapy + scaffold (bone marrow stromal cells on acellular spinal cord scaffold), preclinical; no matching trial identified
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24375695 ↗2013Reported benefit

Acellular spinal cord scaffold seeded with bone marrow stromal cells protects tissue and promotes functional recovery in spinal cord-injured rats.

RatSpinal cord injuryHemisection / partialSprague-DawleyMaleImplantation of the seeded scaffold into the injured spinal cord siteAt the time of injury surgery

Model: Acute hemisected spinal cord injury

Scaffolds seeded with bone marrow stromal cells produced significantly better locomotor recovery than scaffold alone or no treatment at 2 and 8 weeks (P<0.05), with surviving grafted cells differentiating into glial cells and reduced caspase-3 activation at 8 weeks (P<0.05).

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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