Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury.
MouseSpinal cord injuryUnspecifiedC57BL/6 background, GFP-labelled microglia and Thy1 YFP-labelled axons, plus Tlr2 knockout crossed to Thy1 YFPSterile stimulation of microglia in the acute phase after laser injury
Model: Laser-induced focal white matter injury of the living spinal cord imaged by time-lapse two-photon and spectral confocal microscopy, with Nile Red myelin labelling
Pam2CSK4 increased the microglial response to ablation, reduced secondary degeneration of central myelinated fibres and induced an alternative microglial activation profile, whereas Tlr2 knockout mice experienced greater axonal dieback than littermate controls, and blocking microglial release of ne…
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