THERAPY DOSSIER · th-09e8580686a9

Pam2CSK4 (Toll-like receptor 2 agonist lipopeptide)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04313023 ↗PHASE2completed

Phase 2 study of PUL-042 inhalation solution (contains Pam2CSK4) to reduce infection rate and progression to COVID-19 after SARS-CoV-2 exposure

COVID-19

Enrolment: 217 · Results not recorded

NCT04312997 ↗PHASE2completed

Phase 2 study of PUL-042 inhalation solution to reduce severity of COVID-19 in SARS-CoV-2 positive adults

COVID-19

Enrolment: 101 · Results not recorded

NCT06665100 ↗PHASE2recruiting

PUL-042 inhalation solution to reduce lower respiratory tract complications in haematologic malignancy/HSCT patients with PIV, hMPV or RSV

Hematologic Malignancies · Hematopoietic Stem Cell Transplant (HSCT)

Enrolment: 100 · Results not recorded

NCT02124278 ↗PHASE1completed

Single ascending dose study of PUL-042 inhalation solution in healthy subjects

Healthy

Enrolment: 42 · Results not recorded

NCT03097796 ↗PHASE1withdrawn

Multiple ascending dose study of PUL-042 inhalation solution in haematologic malignancies and stem cell transplant recipients

Hematologic Diseases · Stem Cell Transplants

Enrolment: 0 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24369381 ↗2013Reported benefit

Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury.

MouseSpinal cord injuryUnspecifiedC57BL/6 background, GFP-labelled microglia and Thy1 YFP-labelled axons, plus Tlr2 knockout crossed to Thy1 YFPSterile stimulation of microglia in the acute phase after laser injury

Model: Laser-induced focal white matter injury of the living spinal cord imaged by time-lapse two-photon and spectral confocal microscopy, with Nile Red myelin labelling

Pam2CSK4 increased the microglial response to ablation, reduced secondary degeneration of central myelinated fibres and induced an alternative microglial activation profile, whereas Tlr2 knockout mice experienced greater axonal dieback than littermate controls, and blocking microglial release of ne…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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