Effect of dexmedetomidine on lung ischemia-reperfusion injury.
Model: Tracheotomy and mechanical ventilation under pentobarbital 50 mg/kg intraperitoneally with atropine 0.25 mg intramuscularly, left anterolateral thoracotomy through the fourth intercostal space, heparin 100 U/kg intravenously, then occlusion of the left pulmonary hilum with a non-invasive microvascular clip for 1 hour of ischaemia followed by 2 hours of reperfusion; sham animals had thoracotomy without clamping
Dexmedetomidine pre-treatment lowered the lung injury score from 8.8 plus or minus 0.4 to 4.0 plus or minus 0.6 at 2.5 micrograms/kg/hour and 3.0 plus or minus 0.9 at 5 micrograms/kg/hour, reduced the wet to dry ratio and myeloperoxidase activity and lowered lavage TNF-alpha and IL-6, with TLR4 and…
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