Hyperbaric oxygen alleviates experimental (spinal cord) injury by downregulating HMGB1/NF-kappaB expression.
RatSpinal cord injuryUnspecifiedSprague-DawleyAfter acute spinal cord injury, with outcomes measured at days 1, 3, 7 and 14
Model: Acute experimental spinal cord injury; the specific injury procedure is not described in the retrieved abstract
Hyperbaric oxygen reduced HMGB1 mRNA and protein at days 7 and 14 (P<0.05) and NF-kappa B mRNA and protein at days 3, 7 and 14 (P<0.05), with a significant increase in the Basso, Beattie and Bresnahan score at days 7 and 14 (P<0.05).
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.