Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus.
Model: Lithium chloride 3 meq/kg intraperitoneally about 3 hours before pilocarpine, methyl scopolamine nitrate 5 mg/kg intraperitoneally 30 minutes before, then pilocarpine hydrochloride 30 mg/kg intraperitoneally to induce status epilepticus (defined as Racine stage 3), terminated with diazepam 10 mg/kg intraperitoneally at 90 minutes plus a second 10 mg/kg dose 30 to 40 minutes later
Dexamethasone worsened outcome, with hippocampal T2 at 2 days of 55.3 ms at 10 mg/kg and 55.0 ms at 2 mg/kg versus 52.1 ms for untreated status epilepticus and 45.6 ms for controls, significantly higher piriform T2 at 2 and 4 days (p=0.01 and p=0.04), significantly lower relative hippocampal volume…
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