Curcumin treatment protects against renal ischemia and reperfusion injury-induced cardiac dysfunction and myocardial injury.
RatIschaemia-reperfusionRenalSprague-Dawleyn = 30 rats evenly divided into 3 groups (10 per group)Pre-treatment, given before induction of renal ischaemia
Model: Renal ischaemia and reperfusion injury induced by bilateral occlusion of the renal pedicles for 45 minutes followed by 3 hours of reperfusion, with assessment of remote cardiac injury
Renal ischaemia-reperfusion reduced stroke volume, ejection fraction and systolic pressure and raised CK-MB, cardiac troponin I, creatinine and blood urea nitrogen. Curcumin pre-treatment ameliorated ESPVR, improved cardiac contractility and attenuated both myocardial and renal injury, attributed t…
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