Macrophage phenotype controls long-term AKI outcomes--kidney regeneration versus atrophy.
MouseIschaemia-reperfusionRenalC57BL/6 wild-type and IRAK-M deficient (IRAK-M-/-) miceFemale
Model: Postischaemic acute kidney injury (renal ischaemia-reperfusion), with long-term follow-up to 5 weeks; bacterial CpG DNA injection used as an additional TLR9 challenge in wild-type mice
Wild-type kidneys regenerated completely within 5 weeks of acute kidney injury, whereas IRAK-M deficient kidneys progressively lost up to two-thirds of their original mass through tubule loss, with interstitial M1 macrophage accumulation and increased proinflammatory cytokine and chemokine expressi…
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