Chronic curcumin treatment normalizes depression-like behaviors in mice with mononeuropathy: involvement of supraspinal serotonergic system and GABAA receptor.
MouseOtherICRmaleoral (p.o.)45 mg/kg
Model: Chronic constriction injury (CCI) of the sciatic nerve producing mononeuropathy
Chronic oral curcumin corrected both the thermal hyperalgesia and the prolonged immobility (depressive-like behaviour) of neuropathic mice. The antidepressant-like action was abolished by brain serotonin depletion but not noradrenaline depletion, blocked by repeated WAY-100635 and greatly attenuate…
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