Bone marrow cell mobilization by the systemic use of granulocyte colony-stimulating factor (GCSF) improves wound bed preparation.
MouseWoundSystemic injection (specific route not stated)
Model: Full-thickness tail wounds in mice with dorsally implanted polyvinyl alcohol sponges, plus green fluorescent protein bone marrow chimeric mice for homing studies; proof of principle in one patient with a nonhealing venous ulcer
Systemic GCSF mobilised bone marrow stem cells into the peripheral blood and to the wound site, and was associated with increased collagen accumulation and promising wound bed preparation and healing, including in a patient with a nonhealing venous ulcer. No quantitative effect sizes were reported…
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