Doxycycline attenuates burn-induced microvascular hyperpermeability.
RatBurnUnspecifiedSprague-DawleyMalen = n=5 per group (sham, burn, burn plus doxycycline)
Model: 30 per cent total body surface area full-thickness burn; parallel in vitro studies using rat lung microvascular endothelial cells treated with sera from sham or burned animals
MMP-9 levels rose after burn injury. Burn serum significantly increased endothelial monolayer permeability and disrupted the adherens junction complex, and both effects were attenuated by doxycycline and by a specific MMP-9 inhibitor (p<0.05). Intravital microscopy confirmed microvascular hyperperm…
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