Substance P attenuates hyperoxia-induced lung injury in neonatal rats.
RatOtherSprague-DawleyIntraperitonealConcurrent with hyperoxia exposure
Model: Hyperoxia-induced acute lung injury (exposure to 95% O2 for up to 14 days)
Substance P significantly ameliorated hyperoxia-induced lung damage, decreased MDA, significantly increased SOD and markedly increased SHH expression compared with hyperoxia alone.
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