Topical hypochlorite ameliorates NF-kappaB-mediated skin diseases in mice.
MouseRadiationC57BL/6; NF-kappaB reporter and transgenic micefemaleTopical (cutaneous)
Model: Acute radiation dermatitis induced by localised ionising radiation to the skin; also LPS-induced cutaneous NF-kappaB activation and chronological skin ageing
Topical hypochlorite reduced LPS-induced cutaneous NF-kappaB signalling, suppressed NF-kappaB-dependent gene expression in acute radiation dermatitis, decreased disease severity and prevented skin ulceration. In aged mice it attenuated p16INK4a production and Rad50 expression and increased epiderma…
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