THERAPY DOSSIER · th-91c45c0db552

Hypochlorite (hypochlorous acid, HOCl), applied topically

Drug

No trauma translation Suggest a correction

Review required. This record is flagged as borderline.

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Topical antiseptic / wound cleanser; marketed HOCl wound-care products (device/OTC-type clearances). No single systemic drug approval; ChEMBL first_approval null
First approval: Not recorded
Development stage: Marketed topical antiseptic/wound cleanser; regulatory pathway (device/OTC) not a specific acute-injury drug approval
ChEMBL record: CHEMBL1616046 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Comfosy; Epicyn hydrogel; Hypochlorous acid
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05175027 ↗NAcompleted

Comparison of Povidone Iodine and Hypochlorous Acid Used as a Preoperative Antiseptic in Neonatal Circumcision

Newborn; Infection · Disinfection · Circumcision

Enrolment: 60 · Results not recorded

NCT05988788 ↗NAcompleted

Effect of Epigallocatechin-3-Gallate Solution Versus Sodium Hypochlorite as a Root Canal Irrigant on Post-Operative Pain Intensity and Bacterial Load Reduction in Asymptomatic Necrotic Mandibular Premolars: A Randomized Clinical Trial

Necrotic Pulp

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24231355 ↗2013Reported benefit

Topical hypochlorite ameliorates NF-kappaB-mediated skin diseases in mice.

MouseRadiationC57BL/6; NF-kappaB reporter and transgenic micefemaleTopical (cutaneous)

Model: Acute radiation dermatitis induced by localised ionising radiation to the skin; also LPS-induced cutaneous NF-kappaB activation and chronological skin ageing

Topical hypochlorite reduced LPS-induced cutaneous NF-kappaB signalling, suppressed NF-kappaB-dependent gene expression in acute radiation dermatitis, decreased disease severity and prevented skin ulceration. In aged mice it attenuated p16INK4a production and Rad50 expression and increased epiderma…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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