Ketogenic diet improves forelimb motor function after spinal cord injury in rodents.
MixedSpinal cord injuryContusionSprague-Dawley rats; C57Bl/6 mice for the 4-CIN experimentmalen = Seven experiments; experiment 1 n=9 ketogenic versus n=18 s…Oral (dietary)Diet composition 65.8% fat, 3.0% carbohydrate, 18.1% protei…Started 4 hours after injury
Model: C5 unilateral hemi-contusion of the cervical spinal cord
Post-injury ketogenic diet increased forepaw usage and range of motion, improved pellet retrieval with recovery of wrist and digit movement, and the improvement persisted after returning to standard diet. Lesion areas were smaller with greater grey matter sparing, and GLUT1-positive vessels and MCT…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.