THERAPY DOSSIER · th-d1043d768d91

Ketogenic diet with a 3:1 ratio of fat to carbohydrate plus protein (Bio-Serv F5848)

Nutraceutical · Dietary intervention (ketogenic diet); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Dietary intervention (ketogenic diet); not a ChEMBL entity
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02216500 ↗NArecruiting

Precision Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy

Seizures

Enrolment: 400 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24223849 ↗2013Reported benefit

Ketogenic diet improves forelimb motor function after spinal cord injury in rodents.

MixedSpinal cord injuryContusionSprague-Dawley rats; C57Bl/6 mice for the 4-CIN experimentmalen = Seven experiments; experiment 1 n=9 ketogenic versus n=18 s…Oral (dietary)Diet composition 65.8% fat, 3.0% carbohydrate, 18.1% protei…Started 4 hours after injury

Model: C5 unilateral hemi-contusion of the cervical spinal cord

Post-injury ketogenic diet increased forepaw usage and range of motion, improved pellet retrieval with recovery of wrist and digit movement, and the improvement persisted after returning to standard diet. Lesion areas were smaller with greater grey matter sparing, and GLUT1-positive vessels and MCT…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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