Mechanism of ulinastatin protection against lung injury caused by lower limb ischemia-reperfusion
RatIschaemia-reperfusionLimb / skeletal muscleSprague-DawleyMaleIntravenousPre-treatment, before limb ligation
Model: Remote lung injury from lower limb ischaemia-reperfusion, rubber band ligation of the lower limbs for 3 hours followed by 3 hours of reperfusion
Lower limb ischaemia-reperfusion caused marked pulmonary inflammatory cell infiltration, haemorrhage and oedema, a fall in oxygenation index, increased lavage white cell count and raised lavage TNF-alpha, IL-1 and IL-6, with increased phosphorylated ERK, JNK and p38. Intravenous ulinastatin pre-tre…
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