Sandwich-type fiber scaffolds with square arrayed microwells and nanostructured cues as microskin grafts for skin regeneration
MixedWoundLewisMalen = 9 male Lewis rats randomised into 3 groups of n = 3 for the…Topical application onto the wound bed with radially aligned fibres facing the wound, secured with gauze pads, rat jackets and self-adherent wrap1 mm diameter autologous microskin tissue per microwell; mi…Applied immediately at the time of wound creation
Model: One 2 cm diameter circular full-thickness skin excision through the panniculus carnosus on each side of the dorsum, created with a biopsy punch and iris scissors
Sandwich-type scaffolds adhered tightly to the wound bed, held microskin grafts in a uniform square array, allowed exudate drainage and limited wound contraction compared with petrolatum gauze. Histology showed microskin graft take close to 100 percent with epidermal and dermal layers intact and re…
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