THERAPY DOSSIER · th-3d351876d28c

Sandwich-type electrospun poly(epsilon-caprolactone) nanofibre scaffold with radially aligned nanofibres at the bottom and a nanofibre membrane with square arrayed microwells and nanotopographic cues on top, carrying 1 mm diameter autologous microskin grafts in between

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24144904 ↗2013Reported benefit

Sandwich-type fiber scaffolds with square arrayed microwells and nanostructured cues as microskin grafts for skin regeneration

MixedWoundLewisMalen = 9 male Lewis rats randomised into 3 groups of n = 3 for the…Topical application onto the wound bed with radially aligned fibres facing the wound, secured with gauze pads, rat jackets and self-adherent wrap1 mm diameter autologous microskin tissue per microwell; mi…Applied immediately at the time of wound creation

Model: One 2 cm diameter circular full-thickness skin excision through the panniculus carnosus on each side of the dorsum, created with a biopsy punch and iris scissors

Sandwich-type scaffolds adhered tightly to the wound bed, held microskin grafts in a uniform square array, allowed exudate drainage and limited wound contraction compared with petrolatum gauze. Histology showed microskin graft take close to 100 percent with epidermal and dermal layers intact and re…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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