The effects of dimethyl sulfoxide on the acute phase of experimental acid and alkali corrosive esophageal burns
RatBurnChemical / corrosiveSprague-DawleyMalen = 50 male rats, 10 per group across 5 groupsIntraperitonealFirst dose 15 minutes after burn creation
Model: Corrosive oesophageal burn of the distal oesophagus created with 1 N hydrochloric acid (acid burn) or 50 percent sodium hydroxide (alkali burn)
Dimethyl sulfoxide significantly reduced the severity of acute macroscopic and microscopic tissue damage in both acid and alkali corrosive oesophagitis, significantly suppressed the raised Ki-67 proliferation index in the alkali group and significantly reduced NF-kappaB immunoreactivity in both bur…
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