Neuroprotective effects of ebselen in traumatic brain injury model: involvement of nitric oxide and p38 mitogen-activated protein kinase signalling pathway
RatTBIWeight-drop / impact-accelerationSprague-DawleyMalen = 90 rats total, randomly divided into five groups of n = 18Intragastric3, 10 or 30 mg/kg
Model: Modified weight-drop traumatic brain injury
Ebselen significantly ameliorated neurological injury in a dose-dependent manner, lowering neurological severity score, brain water content and histopathological damage, and reduced nitric oxide and iNOS mRNA while inhibiting TLR4 and phosphorylated p38 MAPK expression.
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