Propofol impairs neurogenesis and neurologic recovery and increases mortality rate in adult rats after traumatic brain injury
RatTBIControlled cortical impactSprague-DawleyMalen = 116 male Sprague-Dawley rats in total; per-group numbers no…Infusion, specific route not stated36 or 72 mg/kg/hEither during controlled cortical impact induction or in a delayed protocol beg…
Model: Controlled cortical impact traumatic brain injury
Propofol aggravated neurological dysfunction, increased 28-day mortality and impaired post-traumatic neurogenesis, with a significantly stronger effect at the high dose when given during trauma induction; the delayed post-trauma protocol also increased mortality and impaired neurological function a…
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