Possible involvement of cathepsin B/D and caspase-3 in deferoxamine-related neuroprotection of early brain injury after subarachnoid haemorrhage in rats.
RatHaemorrhage/shockUnspecifiedMaleIntraperitonealAfter subarachnoid haemorrhage, with outcomes assessed 48 h after blood injecti…
Model: Subarachnoid haemorrhage induced by a single injection of autologous blood into the prechiasmatic cistern
Cathepsin B/D and caspase-3 rose in the cortex after subarachnoid haemorrhage and peaked at 48 h. Intraperitoneal deferoxamine downregulated this elevated expression at 48 h and significantly ameliorated brain oedema, blood-brain barrier impairment, cortical apoptosis and behavioural deficits relat…
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