Protective effect of a direct renin inhibitor in acute murine model of cardiotoxicity and nephrotoxicity.
RatChemical/toxinWistarOral100 mg/kgPretreatment before doxorubicin challenge
Model: Doxorubicin-induced acute cardiotoxicity and nephrotoxicity, doxorubicin 15 mg/kg intraperitoneally as a single dose
Aliskiren 100 mg/kg orally for 14 days significantly prevented the doxorubicin-induced rises in angiotensin I, caspase-3, lactate dehydrogenase, malondialdehyde, urea and creatinine and the falls in albumin, total protein, glutathione and superoxide dismutase, and limited myocardial and renal ultra…
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