Activation of heme oxygenase recovers motor function after spinal cord injury in rats.
RatSpinal cord injuryUnspecifiedWistarFemaleHemin given 2 h and 8 h after spinal cord injury
Model: Traumatic spinal cord injury produced by trauma
Heme oxygenase activity increased after injury at all times measured and was raised 7.2-fold at 24 h by hemin compared with injury plus vehicle. Rats treated with hemin at 2 h and 8 h showed better motor recovery and more spared cord tissue, indicating that heme oxygenase activation is beneficial i…
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