Addition of nitrous oxide to the carbon dioxide pneumoperitoneum strongly decreases adhesion formation and the dose-dependent adhesiogenic effect of blood in a laparoscopic mouse model.
MouseOtherBALB/cFemaleIntraperitoneal insufflation as part of the pneumoperitoneum gasNitrous oxide at 5%, 10%, 25%, 50% or 100% of the pneumoper…During the 60-minute pneumoperitoneum at the time of surgery
Model: Laparoscopic surgical peritoneal injury with 60-minute carbon dioxide pneumoperitoneum, with intraperitoneal blood, plasma or red blood cells added in some groups
Nitrous oxide strongly reduced adhesion formation with a full effect from 5% to 10%, and 10% nitrous oxide was the most effective factor both in control animals and after adding blood. Adhesions increased linearly with 0.125 mL to 1 mL of added blood, with plasma the main adhesiogenic fraction.
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