THERAPY DOSSIER · th-ca258109345e

Nitrous oxide added to the carbon dioxide pneumoperitoneum, tested with and without added oxygen

Procedure · Procedure (nitrous oxide added to CO2 pneumoperitoneum); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Procedure (nitrous oxide added to CO2 pneumoperitoneum); not a ChEMBL entity
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01340989 ↗NAcompleted

Adding Oxygen and Nitrous Oxide to CO2 Pneumoperitoneum Upon CO2 Resorption

Pneumoperitoneum

Enrolment: 60 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24112528 ↗2013Reported benefit

Addition of nitrous oxide to the carbon dioxide pneumoperitoneum strongly decreases adhesion formation and the dose-dependent adhesiogenic effect of blood in a laparoscopic mouse model.

MouseOtherBALB/cFemaleIntraperitoneal insufflation as part of the pneumoperitoneum gasNitrous oxide at 5%, 10%, 25%, 50% or 100% of the pneumoper…During the 60-minute pneumoperitoneum at the time of surgery

Model: Laparoscopic surgical peritoneal injury with 60-minute carbon dioxide pneumoperitoneum, with intraperitoneal blood, plasma or red blood cells added in some groups

Nitrous oxide strongly reduced adhesion formation with a full effect from 5% to 10%, and 10% nitrous oxide was the most effective factor both in control animals and after adding blood. Adhesions increased linearly with 0.125 mL to 1 mL of added blood, with plasma the main adhesiogenic fraction.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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