High-dose glucocorticoid aggravates TBI-associated corticosteroid insufficiency by inducing hypothalamic neuronal apoptosis.
RatTBIFluid percussionWistarMale1 or 10 mg/kg in vivo, and 10^-5 to 10^-8 mol/L in vitroAfter traumatic brain injury, with corticosteroid insufficiency assessed on pos…
Model: Fluid percussion injury induced traumatic brain injury in vivo, with primary cultured rat hypothalamic neurons in vitro
The incidence of acute critical illness related corticosteroid insufficiency was significantly higher in the high-dose dexamethasone group on post-injury day 7. High-dose dexamethasone reduced cultured hypothalamic neuron viability from 12 to 24 h, increased TUNEL-positive cells by 18 h, and thinne…
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