Metformin-stimulated AMPK-alpha1 promotes microvascular repair in acute lung injury.
RatEndotoxin/LPSSprague-DawleyMale
Model: Endotoxin (lipopolysaccharide) induced acute lung injury in vivo, isolated perfused lung ex vivo, and cultured rat pulmonary microvascular endothelial cells in vitro
AMPK stimulation with metformin or AICAR decreased the lipopolysaccharide-induced rise in filtration coefficient and resolved oedema as shown by lower wet-to-dry ratios. shRNA knockdown of AMPK-alpha1 in capillary endothelial cells identified this isoform as responsible for the benefit, supporting…
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