(-)-Epigallocatechin-3-gallate (EGCG) modulates neurological function when intravenously infused in acute and, chronically injured spinal cord of adult rats.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 72 adult female rats randomised across four treatment group…Intravenous infusionAcute group treated within the first 4 h after injury; chronic group treated on…
Model: Moderate thoracic contusion spinal cord injury using the MASCIS impactor
Intravenous EGCG infused for 36 h improved locomotor and sensory recovery and pain thresholds in both acute and one-year chronic injured rats, and reduced lesion size and increased neuronal numbers in the acute group.
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