In vitro/in vivo characterization of nanocrystalline formulation of tranilast with improved dissolution and hepatoprotective properties.
RatChemical/toxinSprague-DawleyMaleOral2 mg tranilast per kgRepeated treatment in a carbon tetrachloride treated rat model of acute liver i…
Model: Carbon tetrachloride induced acute liver injury in rats
Nanocrystalline tranilast at 2 mg/kg every 12 h markedly attenuated hepatic damage with lower alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and reactive oxygen species, whereas the physical mixture was less effective.
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